Road traffic crashes (RTCs) remain an issue of global concern particularly in Nigeria where over 80 percent of these crashes are accounted by human and mechanical factors (HM). Many geographic studies on RTCs, fatality and injury have largely focused on the spatial clustering and associative analysis of risk factors; with little known about the relative contribution of HM factors within the spatial context. Hence, this study applied a spatial approach to the effect of HM factors on RTCs, fatality and injury across the regions of Nigeria. The data for this study were obtained from the National Bureau of Statistics for the year 2017-2019 and were analysed using spatial analysis techniques such as Global Moran’s I and spatial regression model. There was evidence of geographic clustering of RTCs, fatality and injury in Nigeria.